The central joke of Serious Sam is that he isn't very serious at all. And nor are his games. In fact, they're extremely silly, and if they don't start behaving they're not going to get any sweets. Yes, Croteam's long-running flagship FPS is a gleefully daft blaster that revels in throwing as many enemies at you as possible, creating huge, ridiculous battle sequences that can be genuinely exhilarating.
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5/10 seems bit harsh. I can't comment much tho cause I've never seen or played any of these except the first one for about 20 minutes at friends house. But imo there needs to be a serious issue to merit such a loss of points. Like there's a game I'm not gonna mention atm that I love to defend, but it HAS a fatal flaw that has still yet to be fixed. So yea it can def sit at it's real life score of 5/10 and I understand why. Good game with an unfixed fatal glitch. I don't get the low score on this review. Only real issue was with frame rate on 1 game of the series set. Oh well, to each their own.
Discussion on the variable can be found in Proton issue #1209. Lower values maintain lower audio latency but crackling may still occur; higher values are more likely to eliminate crackling but allow for higher audio latency.
This section, method, or task contains steps that tell you how to modify the registry. However, serious problems might occur if you modify the registry incorrectly. Therefore, make sure that you follow these steps carefully. For added protection, back up the registry before you modify it. Then, you can restore the registry if a problem occurs. For more information about how to back up and restore the registry, click the following article number to view the article in the Microsoft Knowledge Base:322756 How to back up and restore the registry in Windows
However, the most serious side effect of antimuscarinic drugs is AUR. Because of their effect on the bladder (detrusor flaccidity), antimuscarinics are closely associated with AUR. A retrospective cohort study suggested that patients receiving antimuscarinic treatment for one month had a higher incidence of AUR than patients receiving long-term treatment (8.3 vs. 2.0) (Martín-Merino et al., 2009). The risk of AUR also seems to be higher during the early stages of antimuscarinic treatment. In terms of the risk of AUR, another meta-analysis, involving randomized controlled trials (RCTs) and observation studies, 365 men, and a 12-week follow-up period, suggested that the incidence of AUR was only small (0.3%) (Blake-James et al., 2007). According to the AUA Guidelines on the Management of Benign Prostatic Hyperplasia, LUTS-BPH patients with a PVR > 250 to 300 ml should only receive antimuscarinic treatment with caution. The AUA guideline also recommends that MRAs should only be prescribed after investigating a patient's PVR (Mcvary et al., 2011). Another meta-analysis investigated the relationship between age and the safety of antimuscarinics in older adults. It appears that the treatment of LUTS patients with antimuscarinics increases the risk of side effects in patients aged 65 or older when compared with patients younger than 65 years of age (Vouri et al., 2017). This result may be associated with drug metabolism and the fact that elderly individuals generally exhibit lower rates of metabolism, thus prolonging the drug residence time.
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